Exosomes Derived From Placental Stem Cells
Dr. Goldstein
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Why Exosomes Derived From Placental Stem Cells For Treatment For Hair Loss?
In addition to PRP which has been in wide-spread use for over eight years, there are other sources of novel and cellular therapy for regeneration of hair follicles. Those sources include autologous human stem cells originating from adipose and bone marrow. Placental cell-derived stem cells have also been used with reportedly excellent results. The latest advance uses exosomes, a cell-produced substance inside these placental stem cells that produces better results than stem cells alone.
While exosomes can be harvested from a variety of human adult cells, not all sources of exosomes have the same biological restorative strength. The most powerful exosomes are derived from human placental mesenchymal stem cells.
What Can I Expect From Exosome Treatment?
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The safety and tolerability of the BioGenix™ exosomes is known, however, no scientific studies or case reports are available in hair restoration patients to determine its efficacy. No guarantee of success can be made with this FDA-approved product, and clinical responses to these medical therapies vary from one patient to another. Treatment for hair loss with novel regenerative therapies is exciting with safety and tolerability well-established, but efficacy studies still outstanding. The use of placental-derived stem call exosomes are recent developments and large-scale studies have not been conducted.
What are Exosomes?
Exosomes are not stem cells. They are found within the stem cell’s microvessicles and contain no nucleus or DNA. It is viewed as one of the purest forms of cellular therapy available, as their function provides tissue stimulation and wound healing by triggering the patient’s own regenerative cells to become active.
Exosomes are the latest generation of naturally bioactive amnion-based products for patient treatment of hair thinning and loss. Exosomes act as paracrine effectors, i.e., they have a role in signaling or stimulating nearby cells. The stimulating effect upon tissues and cells is caused by transferring biochemical stimulating contents from one cell to another. These messengers are termed exosomes and microvesicles, collectively known as extracellular vesicles (EVs).
How Do Exosomes Work in Hair Stimulation?
Regenerative cells by nature work to heal, repair, stimulate, and restore cells and tissues. The hair follicle is susceptible and vulnerable to miniaturization and loss by genetic and hormonal effects from DHT as well as from a number of other causes. It is not known how the presence of other causes will affect the exosome treatment.
How Are The Extracellular Vesicles Injected Into The Scalp?
The tiny size of EVs allows for easy injection into the superficial dermis of the scalp. The procedure is performed in the same manner as other simple procedures done in my office such as PRP injections.